- Title
- Checkpoint immunotherapy for cancer: superior survival, unaccustomed toxicities
- Creator
- Gedye, C.; van der Westhuizen, A.; John, T.
- Relation
- NHMRC.628939 http://purl.org/au-research/grants/nhmrc/628939
- Relation
- Internal Medicine Journal Vol. 45, Issue 7, p. 696-701
- Publisher Link
- http://dx.doi.org/10.1111/imj.12653
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2015
- Description
- Novel cancer immunotherapy antibodies are moving from clinical trials into routine practice, delivering sustained benefits and prolonged survival to patients with melanoma, lung, kidney and other cancers. These immunostimulatory antibodies non-specifically activate the patient's own immune system by inhibiting immune system checkpoint proteins. This mechanism of action is entirely different to traditional cancer treatments, such as chemotherapy. While there are virtually no immediate toxicities, serious life-threatening autoimmune side-effects such as colitis, dermatitis, hypophysitis, pneumonitis and hepatitis can occur, sometimes starting long after the treatment has been given. Recognition, referral and prompt treatment with immunosuppressive drugs like corticosteroids can control these immune-related side-effects without compromising efficacy. This exciting new class of drugs is defining a new paradigm in cancer therapy.
- Subject
- immunotherapy; checkpoint protein; cancer; melanoma; lung cancer; immune-related side-effect
- Identifier
- http://hdl.handle.net/1959.13/1333246
- Identifier
- uon:27041
- Identifier
- ISSN:1445-5994
- Rights
- This is the peer reviewed version of the following article: Gedye, C.; van der Westhuizen, A.; John, T. "Checkpoint immunotherapy for cancer: superior survival, unaccustomed toxicities” Internal Medicine Journal Vol. 45, Issue 7, p. 696-701which has been published in final form at http://dx.doi.org/10.1111/imj.12653. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
- Language
- eng
- Full Text
- Reviewed
- Hits: 2953
- Visitors: 3525
- Downloads: 618
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Author final version | 615 KB | Adobe Acrobat PDF | View Details Download |